Prion Protein
Prion Protein is a protein that is converted from a normal cell protein (PrPC) to a pathogenic conformation (PrPSc). PrPC is an α-helices rich membrane glycoprotein, which regulates neuronal development, synaptic function, intercellular signaling, cellular oxidative stress response, and apoptosis under normal physiological conditions. PrPC is converted into β-folding rich PrPSc under pathological conditions, leading to neuronal damage and death. Prion Protein dysfunction and misfolding causes prion diseases such as Creutzfeldt-Jakob Disease (CJD), Fatal Familial Insomnia (FFI), Gerstmann-Sträussler-Scheinker Syndrome (GSS), and other neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) or Multiple System Atrophy (MSA)[1].
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Prion Protein Related Products (23)
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Radotinib
0 ImagesSynonyms: IY-5511Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases.
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ARN1468
0 ImagesARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM.
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BiCAPPA
0 ImagesBiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM.
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PrP (106-126)
0 ImagesSynonyms: Prion protein (106-126)PrP (106-126) is a peptide corresponding to the prion protein (PrP) amyloidogenic region, and its biochemical properties resemble the infectious form of prion protein.
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IND24
0 ImagesIND24 is a potent antiprion agent with an EC50 value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell.
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Anti-PRNP Antibody
0 ImagesCat. No.: HY-P992294
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H9-KGDEVD-MMAE
0 ImagesCat. No.: HY-183849CAS No.: 1932672-71-3H9-KGDEVD-MMAE is an antibody-drug conjugate that specifically binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE contains a linker cleavable by cathepsin B and caspase-3/7, allowing the release of MMAE in lysosomes. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma.
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Etidaligide sodium scrambled negative control
0 ImagesCat. No.: HY-177631BEtidaligide sodium scrambled negative control is the sequence scrambled negative control of Etidaligide sodium.
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1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one
0 Images1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC50 values of 13 nM and 25 nM, respectively.
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SM875
0 ImagesSM875 is a cellular prion protein (PrP) degrader (IC50: 7.87 μM). SM875 targets PrP folding intermediates and promotes its degradation through the autophagy-lysosomal pathway. SM875 only acts on nascent, immature PrP molecules and has no effect on mature PrP before synthesis. SM875 can inhibit prion replication and has potential in the study of neurodegenerative diseases (i.e., prion diseases).
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Erisonersen
0 ImagesCat. No.: HY-177630CAS No.: 2834724-51-3Synonyms: ION 717Erisonersen, an antisense oligonucleotide, is a prion protein synthesis reducer. It is used for the study of Prion disease.
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BB 0305179
0 ImagesCat. No.: HY-147702CAS No.: 2512200-83-6BB 0305179 (compound 59) is a potent anti-prion agent, with an IC50 of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain . BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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GFP16
0 ImagesCat. No.: HY-153756CAS No.: 749212-56-4GFP16 is a low affinity antiprion compound. GFP16 can be used for research of antiprion drug discovery.
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IND45193
0 ImagesCat. No.: HY-115360CAS No.: 10024-04-1IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.
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IND81
0 ImagesCat. No.: HY-124375CAS No.: 1426047-52-0IND81 is an orally active antiprion with IC50 value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells.
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(R)-SM875
0 ImagesCat. No.: HY-150286ACAS No.: 2715974-36-8(R)-SM875 is a degrader targeting the intermediate folding form of prion protein (PrP). (R)-SM875 significantly reduces the PrP level, with an IC50 of 3 μM. (R)-SM875 can be used for the study of prion diseases.
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Anti-Mouse/Human PrP/prion protein Antibody (TW1)
0 ImagesCat. No.: HY-P990167Anti-Mouse/Human PrP/prion protein Antibody (TW1) is a mouse-derived IgG2a type antibody inhibitor, targeting to mouse/human PrP/prion protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) binds to both PrPc (cellular prion protein) and PrPSc (Scrapie Prion Protein) and blocks the interaction of prion protein with tau protein. Anti-Mouse/Human PrP/prion protein Antibody (TW1) can be used for the researches of Alzheimer’s disease (AD).
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Radotinib-d6
0 ImagesCat. No.: HY-15728SCAS No.: 2754051-83-5Synonyms: IY-5511-d6Radotinib-d6 is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases.
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Erisonersen sodium
0 ImagesCat. No.: HY-177630ACAS No.: 2834724-81-9Synonyms: ION 717 sodiumErisonersen sodium, an antisense oligonucleotide, is a prion protein synthesis reducer. It is used for the study of Prion disease.
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ccβ
0 ImagesCat. No.: HY-P10534CAS No.: 873582-78-6CCβ is a simple 17-amino acid peptide designed in research. CCβ is able to mimic the conformational transition of proteins from α-helix to β-sheet, which is a key step in the aggregation of proteins associated with many diseases, such as Alzheimer's disease and prion disease. CCβ can be used to study diseases related to protein aggregation.
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